1,4-Oxathiane
CAS15980-15-1
1,4-Oxathiane (CAS 15980-15-1), also known as 1,4-thioxane, is a saturated six-membered heterocycle carrying one oxygen and one sulfur atom in the 1,4-positions. The colorless liquid is used as a building block and reagent in organic synthesis, as a precursor to the corresponding sulfoxide and sulfone, and as an analytical reference compound. KingPharm supplies 1,4-Oxathiane for research and production use with a batch-specific certificate of analysis.
- CAS No.
- 15980-15-1
- Formula
- C4H8OS
- Mol. weight
- 104.17 g/mol
Product Description
1,4-Oxathiane (C4H8OS, MW 104.17) is a six-membered saturated ring in which an ether oxygen and a thioether sulfur sit opposite each other. It is a clear, colorless to pale yellow liquid with a boiling point of 147 °C (755 mmHg), a melting point of -17 °C and a density of 1.114 g/mL at 25 °C, and it is slightly soluble in water.
The thioether sulfur is the main reactive site. It can be oxidized to the sulfoxide or sulfone with reagents such as sodium periodate or calcium hypochlorite, chlorinated at low temperature to give 3-chloro-1,4-oxathiane, and converted with halogens or alkylating agents into oxathianium salts. The ether oxygen can act as an O-donor ligand, which is how the compound has been used as an adduct in chemical vapor deposition.
Compared with 1,4-dioxane, which has no sulfur handle, and 1,4-dithiane, a solid with two sulfur atoms, 1,4-Oxathiane combines one ether and one thioether in a single liquid ring. This allows selective chemistry at sulfur while the oxygen remains intact, and the liquid form is convenient for metering in solution-phase work.
When sourcing, check GC purity, water content and related impurities such as 1,4-dithiane, a common by-product of manufacture. The material is a flammable liquid and an irritant, so packaging and transport must follow flammable-liquid requirements. The certificate of analysis and specification should be reviewed for each batch.
Chemical Specifications
Identifiers
| CAS number | 15980-15-1 |
|---|---|
| Product name | 1,4-Oxathiane |
| Chinese name | 1,4-噻恶烷 |
| IUPAC name | 1,4-oxathiane |
| Synonyms | 2,3,5,6-tetrahydro-1,4-Oxathiin; 1,4-Thioxane; 1-Oxa-4-thiacyclohexane; 1-Thia-4-oxacyclohexane; Oxathiane; p-Thioxane |
| Chinese synonyms | 1,4-噻噁烷; 1,4-氧硫六环; 1,4-噻烷 |
| Molecular formula | C4H8OS |
| Molecular weight | 104.17 g/mol |
| EC number | 240-117-6 |
| MDL number | MFCD00006573 |
| PubChem CID | 27596 |
| InChI | InChI=1/C4H8OS/c1-3-6-4-2-5-1/h1-4H2 |
| InChIKey | JBYHSSAVUBIJMK-UHFFFAOYSA-N |
| SMILES | C1CSCCO1 |
Physical and chemical properties
| Refractive index | 1.509 |
|---|
Applications
1,4-Oxathiane is used in synthesis, materials research and analytical work.
Heterocyclic building block
Introduces the 1,4-oxathiane ring into target molecules in pharmaceutical and fine-chemical synthesis.
Sulfoxide and sulfone precursor
Oxidation at sulfur gives 1,4-oxathiane 4-oxide and 4,4-dioxide for further derivatization.
Materials research
Used as an oxygen-donor adduct in the chemical vapor deposition growth of zinc oxide nanowires.
Analytical reference compound
Serves as a reference for GC-MS identification of cyclic sulfur mustard degradation products in environmental samples.
Quality Documentation
The following documents can be provided for 1,4-Oxathiane to support technical evaluation and purchasing. Documents are issued for the specific grade and batch supplied.
-
Certificate of Analysis (COA) Batch-specific test results against the specification.
-
Product specification The release specification with test items, limits and methods.
Packaging, Storage & Transport
| Storage Temp | 室温, 干燥通风，密闭容器<br>Room Temp., Dry, Tighten Container ( ℃ ) |
|---|---|
| Available pack sizes | 25 kg, 10 kg, 1 kg, 500 g, 100 g, 25 g |
Read the current safety data sheet before handling. Packaging can be adapted to the order quantity and destination.
Frequently Asked Questions
How does 1,4-Oxathiane differ from 1,4-dioxane and 1,4-dithiane?
1,4-Oxathiane has one oxygen and one sulfur in the ring, so it offers a thioether site for oxidation, halogenation or alkylation that 1,4-dioxane lacks, while remaining a liquid, unlike solid 1,4-dithiane.
What should be noted when handling 1,4-Oxathiane?
It is a flammable liquid that irritates the skin, eyes and respiratory tract. Handle it in a well-ventilated area away from ignition sources and wear suitable protective equipment.
How should 1,4-Oxathiane be stored?
Keep the container tightly sealed in a dry place at room temperature, away from heat, ignition sources and oxidizing agents.
What is the CAS number of 1,4-Oxathiane?
The CAS Registry Number of 1,4-Oxathiane is 15980-15-1. 1,4-Oxathiane is also known as 2,3,5,6-tetrahydro-1,4-Oxathiin; 1,4-Thioxane; 1-Oxa-4-thiacyclohexane.
What is the molecular formula and molecular weight of 1,4-Oxathiane?
The molecular formula of 1,4-Oxathiane is C4H8OS, and its molecular weight is 104.17 g/mol.
What is 1,4-Oxathiane used for?
1,4-Oxathiane is used in synthesis, materials research and analytical work.
Which quality documents are available for 1,4-Oxathiane?
The following documents are available for 1,4-Oxathiane: Certificate of Analysis (COA); Product specification. Contact KingPharm to request the documents for a specific batch.
How can I request a quotation for 1,4-Oxathiane?
Send an inquiry for 1,4-Oxathiane (CAS 15980-15-1) with the required quantity, target specification, destination country and any documentation requirements. KingPharm will confirm availability, packaging, lead time and price.
Related Products
![1,4-Oxathianium, 4-[4-(1,1-dimethylethyl)phenyl]-, methyl sulfate (1:1)](https://chemsigma.com/chemicalStructure/16/1627528-06-6.png)
Request a Quote for 1,4-Oxathiane
Tell us the required quantity, target specification, destination country and any documentation requirements. We will confirm availability, packaging, lead time and price.
Page last reviewed on by Leo Xiao.