1-Bromo-4-Cyclohexylbenzene
CAS25109-28-8
1-Bromo-4-cyclohexylbenzene (CAS 25109-28-8) is an aryl bromide carrying a cyclohexyl group at the para position. It is used to introduce the 4-cyclohexylphenyl unit through cross-coupling, Grignard or lithiation chemistry, in the synthesis of pharmaceutical intermediates and organic electronic and liquid-crystal materials. It is a colorless to almost colorless liquid. KingPharm supplies 1-bromo-4-cyclohexylbenzene for research and production with a batch-specific certificate of analysis.
- CAS No.
- 25109-28-8
- Formula
- C12H15Br
- Mol. weight
- 239.15 g/mol
- Appearance
- Colorless to Light-yellow Liquid
Product Description
1-Bromo-4-cyclohexylbenzene (C12H15Br, MW 239.15) is a para-disubstituted benzene bearing a bromine atom and a saturated cyclohexyl ring. It is a colorless to almost colorless liquid that is not miscible with water.
The C–Br bond is the reactive site: it undergoes palladium-catalyzed couplings such as Suzuki–Miyaura, Buchwald–Hartwig and Heck reactions, and can be converted into the corresponding Grignard or aryllithium reagent for addition to electrophiles or for borylation. The cyclohexyl group is carried through unchanged, adding a rigid, lipophilic segment to the product.
Compared with the iodo analogue, the bromide is generally more economical and more stable in storage while remaining reactive under standard coupling conditions; compared with the chloro analogue it couples under milder conditions. Using the pre-formed 4-cyclohexylphenyl bromide also avoids installing the cyclohexyl ring late in a synthesis.
When sourcing, check purity (typically by GC), water content where organometallic steps follow, and the level of isomeric and dibrominated impurities. KingPharm provides a batch-specific COA and specification.
Chemical Specifications
Identifiers
| CAS number | 25109-28-8 |
|---|---|
| Product name | 1-Bromo-4-Cyclohexylbenzene |
| Chinese name | 1-溴-4-环己基苯 |
| IUPAC name | 1-bromo-4-cyclohexylbenzene |
| Synonyms | 4-Cyclohexylbromobenzene; p-bromophenylcyclohexane; 4-Bromophenylcyclohexane; 4-Bromo-1-Cyclohexylbenzene |
| Chinese synonyms | 1-溴-4-环己苯; 4-溴环己基苯; 4-溴苯基环己烷 |
| Molecular formula | C12H15Br |
| Molecular weight | 239.15 g/mol |
| EC number | 246-623-3 |
| MDL number | MFCD00019339 |
| PubChem CID | 90718 |
| InChIKey | LVIJLEREXMVRAN-UHFFFAOYSA-N |
| SMILES | C1CCC(CC1)C2=CC=C(C=C2)Br |
Physical and chemical properties
| Appearance | Colorless to Light-yellow Liquid |
|---|
Applications
1-Bromo-4-cyclohexylbenzene is used wherever a 4-cyclohexylphenyl unit needs to be built into a target molecule.
Cross-coupling reactions
Serves as the aryl halide partner in Suzuki–Miyaura, Buchwald–Hartwig and Heck couplings to attach the 4-cyclohexylphenyl group.
Organometallic reagent precursor
Converted to the Grignard or aryllithium reagent to prepare derivatives such as 4-cyclohexylphenylboronic acid or 4-cyclohexylphenol.
Pharmaceutical intermediates
Provides a lipophilic cyclohexylphenyl fragment in the synthesis of drug candidates and intermediates.
Electronic and liquid-crystal materials
Used as a building block for OLED and liquid-crystal compounds containing the cyclohexylphenyl core.
Quality Documentation
The following documents can be provided for 1-Bromo-4-Cyclohexylbenzene to support technical evaluation and purchasing. Documents are issued for the specific grade and batch supplied.
-
Certificate of Analysis (COA) Batch-specific test results against the specification.
-
Product specification The release specification with test items, limits and methods.
Packaging, Storage & Transport
| Available pack sizes | 25 kg, 10 kg, 1 kg, 500 g, 100 g, 25 g |
|---|
Safety and transport
| Hazard Level | 液体普货 |
|---|
Read the current safety data sheet before handling. Packaging can be adapted to the order quantity and destination.
Frequently Asked Questions
Why choose the bromide rather than the iodide or chloride?
The bromide is usually more economical and storage-stable than the iodide while still coupling well under standard Pd conditions, and it reacts under milder conditions than the chloride.
What should be checked before a Grignard or lithiation step?
Confirm low water content and dry the material if needed, since moisture quenches organometallic reagents; the COA reports purity for each batch.
How should 1-bromo-4-cyclohexylbenzene be stored?
Store sealed in a dry place at room temperature.
What is the CAS number of 1-Bromo-4-Cyclohexylbenzene?
The CAS Registry Number of 1-Bromo-4-Cyclohexylbenzene is 25109-28-8. 1-Bromo-4-Cyclohexylbenzene is also known as 4-Cyclohexylbromobenzene; p-bromophenylcyclohexane; 4-Bromophenylcyclohexane.
What is the molecular formula and molecular weight of 1-Bromo-4-Cyclohexylbenzene?
The molecular formula of 1-Bromo-4-Cyclohexylbenzene is C12H15Br, and its molecular weight is 239.15 g/mol.
What is 1-Bromo-4-Cyclohexylbenzene used for?
1-Bromo-4-cyclohexylbenzene is used wherever a 4-cyclohexylphenyl unit needs to be built into a target molecule.
Which quality documents are available for 1-Bromo-4-Cyclohexylbenzene?
The following documents are available for 1-Bromo-4-Cyclohexylbenzene: Certificate of Analysis (COA); Product specification. Contact KingPharm to request the documents for a specific batch.
How can I request a quotation for 1-Bromo-4-Cyclohexylbenzene?
Send an inquiry for 1-Bromo-4-Cyclohexylbenzene (CAS 25109-28-8) with the required quantity, target specification, destination country and any documentation requirements. KingPharm will confirm availability, packaging, lead time and price.
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